Vivienne L. Souter, M.D., Raj P. Kapur, M.D., Ph.D., Dale R. Nyholt, Ph.D., Kristen Skogerboe, Ph.D., David Myerson, M.D., Ph.D., Carl C. Ton, Ph.D., Kent E. Opheim, Ph.D., Thomas R. Easterling, M.D., Laurence E. Shields, M.D., Grant W. Montgomery, Ph.D., and Ian A. Glass, M.D.
Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.
It is an accepted medical doctrine that monochorionic twinsare exclusively monozygous. This doctrine is supported by twostudies that assessed placental pathological features and multipleserologic markers of zygosity in a total of almost 800 monochorionictwins.1,2 Although the possibility that monochorionic twinsare not invariably monozygous has been raised previously, deficienciesin the cytogenetic and pathological characterization of thesereports have cast doubt on their reliability.3 We report a caseof sex-discordant monochorionic twins conceived by in vitrofertilization. The twins also had blood chimerism (the presenceof cells derived from more than one genetically distinct zygote);in . . . [Full Text of this Article]
Case Report
Methods
Placental Studies
Cytogenetic Studies
Initial DNA Zygosity Studies
Extended DNA Zygosity Studies
Statistical Analysis
Results
Placental Studies
Cytogenetic Studies
Initial DNA Zygosity Studies
Extended DNA Zygosity Studies
Discussion
Source Information
From the Division of Medical Genetics, Department of Medicine (V.L.S.), and the Departments of Pathology (D.M.), Obstetrics and Gynecology (T.R.E., L.E.S.), and Pediatrics and Medicine (Medical Genetics) (I.A.G.), University of Washington, Seattle; the Department of Laboratories, Children's Hospital and Regional Medical Center, Seattle (R.P.K., K.E.O.); the Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia (D.R.N., G.W.M.); the Department of Chemistry, Seattle University, Seattle (K.S.); the Fred Hutchinson Cancer Research Center, Seattle (D.M.); and Genelex, Redmond, Wash. (C.C.T.).
Address reprint requests to Dr. Souter at the Department of Obstetrics and Gynecology, Good Samaritan Regional Medical Center, 1111 E. McDowell Rd., Phoenix, AZ 85006, or at vsouter@u.washington.edu.
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