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Radiographs of the right humerus obtained at 4 years of age (Panel A), 24 years of age (Panel B), and 30 years of age (Panel C) in a patient with polyostotic fibrous dysplasia show progressive expansion of osteolytic lesions and increasing bony sclerosis. In this disease, bone forms abnormally because of problems with the differentiation and maturation of osteoblasts. Skeletal lesions of the humerus, skull, facial bones, pelvis, and femurs were first detected when the patient was two years old. At 10 years of age, he had a pathologic fracture of the right femur. At the time of the most . . . [Full Text of this Article] |
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