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Previous Volume 349:1888-1891 November 13, 2003 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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One of the true miracles of modern medicine was the introduction of levodopa, the precursor of dopamine, for the treatment of Parkinson's disease. However, even in the early trials of levodopa, unexpected complications were observed. These included choreoathetotic movements (dyskinesias) and fluctuations from a state of mobility (the "on" period), often accompanied by dyskinesias, to a state of severe parkinsonism ("off" period), sometimes many times a day. These complications become increasingly common and disabling with longer durations of the disease and of exposure to levodopa.

In 1995, researchers from Grenoble, France, first reported that this "levodopa syndrome" responded to high-frequency, . . . [Full Text of this Article]

Source Information

From the University of Toronto, Toronto.

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