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Clinical Implications of Basic Research
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Volume 349:1966-1967 November 13, 2003 Number 20
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Nerves, Fat, and Insulin Resistance
Guenther Boden, M.D., and Robert D. Hoeldtke, Ph.D., M.D.

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Free fatty acids, the chief constituents of fat, are the main fuel for the heart and skeletal muscle under normal circumstances. Under special circumstances — such as exercise or exposure to cold — they become almost the sole source of energy. This change indicates the need for rapid and precise control of the release of free fatty acids. But the relatively quick neuroautonomic regulation of lipolysis has received little attention, while the slower endocrine mechanisms have enjoyed the limelight. A study by Kreier et al.1 signals a change by showing that the parasympathetic nervous system participates in the release of . . . [Full Text of this Article]


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From the Department of Medicine, Temple University Hospital, Philadelphia (G.B.); and West Virginia University, Morgantown (R.D.H.).


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