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Volume 349:1973 November 13, 2003 Number 20
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Long-Term Survivors of Acute Lymphoblastic Leukemia

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by Pui, C.-H.
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To the Editor: Pui et al. (Aug. 14 issue)1 determined the rates of complications and survival among patients who were event-free for at least 10 years after childhood acute lymphoblastic leukemia. Overall survival among patients who had not undergone irradiation was comparable with that of the general U.S. population. However, neither the development of cardiac disease nor death from cardiac disease was mentioned. Increased frequencies of serious cardiac disease and cardiovascular risk factors have been described among survivors of childhood acute lymphoblastic leukemia.2,3 Because of the young age of the patients they studied and the relatively short follow-up period, Pui . . . [Full Text of this Article]



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