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Volume 349:1987-1990 November 20, 2003 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In this issue of the Journal, two reports present data on the efficacy of two new biologic drugs for psoriasis. One of these drugs, etanercept, has been used extensively in rheumatology and targets the pleiotropic inflammatory cytokine tumor necrosis factor (TNF-). The other, efalizumab, targets CD11a, or _L, one chain of _{L 2} integrin, also known as leukocyte-function–associated antigen 1 (LFA-1); LFA-1 is important in the process by which T cells cross blood-vessel walls, enter tissue, and are subsequently activated by antigen. Increasingly, molecules that were once the exclusive domain of immunologic scientists have entered mainstream medicine.

Etanercept consists of the . . . [Full Text of this Article]

Source Information

From the Department of Dermatology, Brigham and Women's Hospital, Boston.

Related Letters:

Etanercept for Crohn's Disease
Travers S. B., Kupper T. S.
Extract | Full Text | PDF  
N Engl J Med 2004; 350:840, Feb 19, 2004. Correspondence

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• Schön, M. P., Boehncke, W.-H. (2005). Psoriasis. NEJM 352: 1899-1912 [Full Text]  
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