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Volume 349:2184-2186 December 4, 2003 Number 23
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Insulin-like Growth Factors and the Basis of Growth
Ron G. Rosenfeld, M.D.

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-Related Article
 by Abuzzahab, M. J.
-PubMed Citation
Growth in any species is an extraordinarily complex process, but growth in humans is characterized by a number of unique features. These include dramatic fetal growth (the most rapid phase of human growth), deceleration of growth immediately after birth, a prolonged growth phase during childhood, prepubertal deceleration, and a pronounced adolescent growth spurt. Although some of these aspects are shared with other mammalian species, others are characteristic only of Homo sapiens and are not replicated even in other primates.

The intricacy of the human growth curve (see Figure) is the product of an evolutionary process expressing the sum effect . . . [Full Text of this Article]


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From the Lucile Packard Foundation for Children's Health, Stanford University, Palo Alto, Calif.; and the Department of Pediatrics, Oregon Health and Science University, Portland.


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