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Volume 349:2267-2268 December 4, 2003 Number 23
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High-Dose Dexamethasone as Initial Treatment for Immune Thrombocytopenic Purpura

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by Cheng, Y.
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To the Editor: Cheng et al. (Aug. 28 issue)1 conclude from their uncontrolled study that a short course of high-dose dexamethasone (40 mg per day for four consecutive days) is an effective treatment for adults with newly diagnosed immune thrombocytopenic purpura. Our prospective, controlled study involving 122 adults with newly diagnosed immune thrombocytopenic purpura and a mean platelet count of less than 10,000 per cubic millimeter clearly demonstrated that intravenous immune globulin (0.7 g per kilogram of body weight per day for three days) was more effective in the short term than high-dose methylprednisolone (15 mg per kilogram per day . . . [Full Text of this Article]



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