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Volume 349:2269 December 4, 2003 Number 23
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Molecular Heterogeneity in Acute Renal Allograft Rejection and DNA Microarrays

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by Sarwal, M.
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To the Editor: The results of the study by Sarwal et al. (July 10 issue)1 are very encouraging for those interested in the underlying pathogenesis of organ rejection, as well as those seeking new laboratory-based diagnostic methods for application to clinical practice. Perhaps the only question concerns the interval between biopsy and the freezing of tissue, which is not stated. Concern has been expressed about the possibility of artifactually induced gene expression in DNA microarray studies, particularly if there is a delay before the tissue is frozen and the tissue is left at room temperature for some time.2 It is . . . [Full Text of this Article]



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