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Volume 349:2285-2287 December 11, 2003 Number 24
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Unstable Coronary-Artery Plaques
Donald D. Heistad, M.D.

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-Related Article
 by Kolodgie, F. D.
-PubMed Citation
It is ironic and instructive that in the age of cellular and molecular biology, great advances in our understanding of the pathophysiology of cardiovascular disease continue to be made by pathologists who perform meticulous and imaginative studies. The concept of stable and unstable atherosclerotic plaques and implications for coronary thrombosis and myocardial infarction can be attributed to several great cardiovascular pathologists during the past century.

What characterizes an arterial plaque that is vulnerable to rupture? What causes the vulnerable plaque to rupture? How can plaque rupture be prevented? These are critically important questions in cardiovascular medicine, because if the causes . . . [Full Text of this Article]


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From the University of Iowa Carver College of Medicine and Veterans Affairs Medical Center, Iowa City.


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