Long-term survival of kidney transplants (renal allografts)has changed little during the past decade, despite dramaticimprovements in short-term survival. Most late renal allograftloss, other than that associated with the death of the patient,has been attributed to progressive renal dysfunction, termed"chronic allograft nephropathy" (or CAN), a confusing term thatlacks a rigorous consensus definition.
Chronic allograft nephropathy entered prime time in 1993 asa category in the Banff diseases of kidney-transplant diseasesthat included at least four entities that could not always bedifferentiated on biopsy (chronic rejection, chronic toxic effectsof cyclosporine; hypertensive vascular disease; and . . . [Full Text of this Article]
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From the Department of Pathology, Massachusetts General Hospital, Boston.
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