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Volume 349:2288-2290 December 11, 2003 Number 24
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Chronic Allograft Nephropathy
Robert B. Colvin, M.D.

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-Related Article
 by Nankivell, B. J.
-PubMed Citation
Long-term survival of kidney transplants (renal allografts) has changed little during the past decade, despite dramatic improvements in short-term survival. Most late renal allograft loss, other than that associated with the death of the patient, has been attributed to progressive renal dysfunction, termed "chronic allograft nephropathy" (or CAN), a confusing term that lacks a rigorous consensus definition.

Chronic allograft nephropathy entered prime time in 1993 as a category in the Banff diseases of kidney-transplant diseases that included at least four entities that could not always be differentiated on biopsy (chronic rejection, chronic toxic effects of cyclosporine; hypertensive vascular disease; and . . . [Full Text of this Article]


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From the Department of Pathology, Massachusetts General Hospital, Boston.


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