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A 12-year-old girl was admitted to the hospital because of fever, vomiting, and an abrupt onset of unresponsiveness.
She had been well until one week earlier, when a cough, sore throat, and rhinorrhea developed. Laboratory values obtained six days before admission are shown in Table 1 and Table 2. On the evening before admission, her temperature was 39.4°C. At noon on the following day, she began to vomit, and at 6:30 p.m. she was taken to the emergency department of another hospital. The temperature was 39.2°C, the pulse was 121 beats per minute, and the blood pressure was 135/75
Differential Diagnosis
Clinical Manifestations of Neisseria meningitidis Infection
Infection Outside the Central Nervous System
Pneumonia
Cardiac Involvement
Cutaneous and Adrenal Findings
Pathophysiology of Meningococcal Infection
Protective Host Factors
Prognostic Factors
Summary
Clinical Diagnosis
Dr. H. Shaw Warren, Jr.'s, Diagnosis
Pathological Discussion
Vaccination and Chemoprophylaxis for Contacts
Anatomical Diagnosis
Source Information
From the Pediatric Infectious Disease Unit, Pediatric Service (H.S.W.), the Department of Medicine (H.S.W.), the Neuroradiology Division, Department of Radiology (R.G.G.), and the Neuropathology Division, Department of Pathology (D.T.), Massachusetts General Hospital; and the Departments of Pediatrics (H.S.W.), Radiology (R.G.G.), and Pathology (D.T.), Harvard Medical School.
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