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Case Records of the Massachusetts General Hospital
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Volume 349:2341-2349 December 11, 2003 Number 24
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Case 38-2003 — A 12-Year-Old Girl with Fever and Coma
H. Shaw Warren, Jr., M.D., R. Gilberto Gonzalez, M.D., and Di Tian, M.D., Ph.D.

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Presentation of Case

A 12-year-old girl was admitted to the hospital because of fever, vomiting, and an abrupt onset of unresponsiveness.

She had been well until one week earlier, when a cough, sore throat, and rhinorrhea developed. Laboratory values obtained six days before admission are shown in Table 1 and Table 2. On the evening before admission, her temperature was 39.4°C. At noon on the following day, she began to vomit, and at 6:30 p.m. she was taken to the emergency department of another hospital. The temperature was 39.2°C, the pulse was 121 beats per minute, and the blood pressure was 135/75 . . . [Full Text of this Article]

Differential Diagnosis

Clinical Manifestations of Neisseria meningitidis Infection

Infection Outside the Central Nervous System

            Pneumonia

            Cardiac Involvement

            Cutaneous and Adrenal Findings

Pathophysiology of Meningococcal Infection

            Protective Host Factors

            Prognostic Factors

Summary

Clinical Diagnosis

Dr. H. Shaw Warren, Jr.'s, Diagnosis

Pathological Discussion

Vaccination and Chemoprophylaxis for Contacts

Anatomical Diagnosis


Source Information

From the Pediatric Infectious Disease Unit, Pediatric Service (H.S.W.), the Department of Medicine (H.S.W.), the Neuroradiology Division, Department of Radiology (R.G.G.), and the Neuropathology Division, Department of Pathology (D.T.), Massachusetts General Hospital; and the Departments of Pediatrics (H.S.W.), Radiology (R.G.G.), and Pathology (D.T.), Harvard Medical School.


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