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Volume 349:2365 December 11, 2003 Number 24
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Mechanisms of Drug Addiction

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by Camí, J.
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To the Editor: Camí and Farré (Sept. 4 issue)1 provide a comprehensive review of the neuronal and behavioral mechanisms involved in drug addiction. Their information on the potential for abuse of cannabinoids, however, is outdated. The authors claim that, in contrast to results obtained with opioids, cocaine, amphetamines, ethanol, and nicotine, "laboratory animals cannot be taught to self-administer {Delta}9-tetrahydrocannabinol." It has been shown that persistent self-administration behavior is maintained with intravenous {Delta}9-tetrahydrocannabinol in animals, with patterns similar to those reported for cocaine given at doses comparable to those present in marijuana smoke inhaled by humans.2 Justinova and colleagues recently demonstrated . . . [Full Text of this Article]



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