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Volume 349:2568-2570 December 25, 2003 Number 26
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Warfarin Prophylaxis in the Antiphospholipid Antibody Syndrome

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by Crowther, M. A.
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To the Editor: The article by Crowther et al. (Sept. 18 issue)1 addresses an important question in the field of hematology. However, the results cannot be used to conclude that moderate-intensity anticoagulation is not inferior to high-intensity anticoagulation for the treatment of recurrent thrombosis in patients with the antiphospholipid antibody syndrome. The confidence interval for the hazard ratio is 0.6 to 15.0 and straddles 1.0, suggesting that if the study were repeated, there is a likelihood of the result being in favor of high-intensity anticoagulation. This possibility is not mentioned in the discussion, and thus readers could be misled with . . . [Full Text of this Article]



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