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Previous Volume 349:209-210 July 17, 2003 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Microsatellites are stretches of DNA in which a short motif (usually one to five nucleotides long) is repeated several times. A typical mononucleotide-repeat microsatellite might be, for instance, a stretch of 13 adenines, abbreviated (A)₁₃. The most common microsatellite in humans is a dinucleotide repeat of cytosine and adenine, (CA)_n, which occurs in tens of thousands of locations in our germ line. Trinucleotide repeats are prone to expansion in meiosis, and when abnormally expanded they lead to a variety of neurologic disorders (such as Huntington's disease, the best known of these) and fragile chromosomal sites (such as the . . . [Full Text of this Article]

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From the Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus.

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