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Previous Volume 349:323-325 July 24, 2003 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Some patients with aortic stenosis have recurrent bleeding into their skin or gastrointestinal tract. Several studies suggest that this bleeding is caused by an acquired defect in von Willebrand factor and that replacement of the aortic valve restores the normal structure of von Willebrand factor and restores normal hemostasis. However, we know little about the prevalence of symptomatic defects in von Willebrand factor in patients with aortic stenosis. In this issue of the Journal, Vincentelli and colleagues (pages 343–349) address this question and provide new information about the response of such hemostatic abnormalities to valve replacement.

Von Willebrand factor circulates . . . [Full Text of this Article]

Source Information

From the Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St. Louis.

This article has been cited by other articles:

• Le Tourneau, T., Susen, S., Caron, C., Millaire, A., Marechaux, S., Polge, A.-S., Vincentelli, A., Mouquet, F., Ennezat, P.-V., Lamblin, N., de Groote, P., Van Belle, E., Deklunder, G., Goudemand, J., Bauters, C., Jude, B. (2008). Functional Impairment of Von Willebrand Factor in Hypertrophic Cardiomyopathy: Relation to Rest and Exercise Obstruction. Circulation 118: 1550-1557 [Abstract] [Full Text]  
• Yoshida, K., Tobe, S., Kawata, M. (2006). Acquired von Willebrand Disease Type IIA in Patients with Aortic Valve Stenosis.. Ann. Thorac. Surg. 81: 1114-1116 [Abstract] [Full Text]  
• Yoshida, K., Tobe, S., Kawata, M., Yamaguchi, M. (2006). Acquired and Reversible von Willebrand Disease With High Shear Stress Aortic Valve Stenosis. Ann. Thorac. Surg. 81: 490-494 [Abstract] [Full Text]