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Previous Volume 349:366-381 July 24, 2003 Number 4 Next

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Prostate cancer is a leading cause of illness and death among men in the United States and Western Europe. Autopsy series have revealed small prostatic carcinomas in up to 29 percent of men 30 to 40 years of age and 64 percent of men 60 to 70 years of age.¹ Moreover, the risk of prostate cancer is 1 in 6 and the risk of death due to metastatic prostate cancer is 1 in 30.² (Figure 1 shows multiple foci of prostate cancer.) With widespread screening for prostate-specific antigen (PSA) and digital rectal examination, as well as early treatment of . . . [Full Text of this Article]

Diet, Lifestyle, and Prostate Cancer

Carcinogens in the Diet

Dietary Components That Protect against Prostate Cancer

Inherited Prostate-Cancer–Susceptibility Genes

RNASEL

MSR1

AR, CYP17, and SRD5A2

Genetic Susceptibility to Prostate Cancer

Somatic Gene Defects in Prostate Cancer

GSTP1

NKX3.1

PTEN

CDKN1B

AR

A Molecular Description of the Prostate-Cancer Cell

Prostatic Inflammation and Prostatic Carcinogenesis

Proliferative Inflammatory Atrophy

Summary

Source Information

From the Departments of Oncology (W.G.N., A.M.D., W.B.I.), Pathology (W.G.N., A.M.D.), and Urology (W.G.N., A.M.D., W.B.I.), Johns Hopkins University School of Medicine, Baltimore.

Address reprint requests to Dr. Nelson at Rm. 151, Bunting-Blaustein Cancer Research Bldg., Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans St., Baltimore, MD 21231-1000, or at bnelson@jhmi.edu.

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