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Volume 349:405-407 July 24, 2003 Number 4
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Management of Drug and Alcohol Withdrawal

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by Kosten, T. R.
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To the Editor: In their informative and practical review of the management of drug and alcohol withdrawal, Kosten and O'Connor (May 1 issue)1 advocate the use of diazepam at a dose of 5 to 10 mg every two to four hours for the management of delirium tremens and withdrawal seizures. They note that longer-acting benzodiazepines have been found to be more effective than placebo in reducing the incidence of seizures and delirium. However, lorazepam may be more effective than diazepam for treating alcohol-withdrawal seizures and status epilepticus. In one study, lorazepam terminated 59.1 percent of episodes of status epilepticus (10 . . . [Full Text of this Article]



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