To the Editor: A novel coronavirus called the severe acute respiratorysyndrome (SARS)associated coronavirus (CoV) has beenidentified as the causal agent of SARS.1,2,3 To understand thehumoral immunity to this virus, we studied the profile of IgMand IgG antibody responses to SARS-CoV. IgM and IgG antibodieswere analyzed by an indirect enzyme-linked immunosorbent assayin 20 patients with SARS from week 1 of their illness to week12 and in 103 healthy contacts.
All 20 patients tested negative for IgM and IgG at week 1 afterthe onset of symptoms. Of these patients, 16 tested positivefor IgM . . . [Full Text of this Article]
This article has been cited by other articles:
Hsu, C.-H., Hwang, K.-C., Chao, C.-L., Chang, S. G. N., Ho, M.-S., Lin, J.-G., Chang, H.-H., Kao, S.-T., Chen, Y.-M., Chou, P.
(2008). An Evaluation of the Additive Effect of Natural Herbal Medicine on SARS or SARS-like Infectious Diseases in 2003: A Randomized, Double-blind, and Controlled Pilot Study. Evid Based Complement Alternat Med
5: 355-362
[Abstract][Full Text]
Cheng, V. C. C., Lau, S. K. P., Woo, P. C. Y., Yuen, K. Y.
(2007). Severe Acute Respiratory Syndrome Coronavirus as an Agent of Emerging and Reemerging Infection. Clin. Microbiol. Rev.
20: 660-694
[Abstract][Full Text]
Yang, L., Peng, H., Zhu, Z., Li, G., Huang, Z., Zhao, Z., Koup, R. A., Bailer, R. T., Wu, C.
(2007). Persistent memory CD4+ and CD8+ T-cell responses in recovered severe acute respiratory syndrome (SARS) patients to SARS coronavirus M antigen. J. Gen. Virol.
88: 2740-2748
[Abstract][Full Text]
Chen, Y.-M. A., Liang, S.-Y., Shih, Y.-P., Chen, C.-Y., Lee, Y.-M., Chang, L., Jung, S.-Y., Ho, M.-S., Liang, K.-Y., Chen, H.-Y., Chan, Y.-J., Chu, D.-C.
(2006). Epidemiological and Genetic Correlates of Severe Acute Respiratory Syndrome Coronavirus Infection in the Hospital with the Highest Nosocomial Infection Rate in Taiwan in 2003. J. Clin. Microbiol.
44: 359-365
[Abstract][Full Text]
Liang, Y., Wan, Y., Qiu, L.-w., Zhou, J., Ni, B., Guo, B., Zou, Q., Zou, L., Zhou, W., Jia, Z., Che, X.-y., Wu, Y.
(2005). Comprehensive Antibody Epitope Mapping of the Nucleocapsid Protein of Severe Acute Respiratory Syndrome (SARS) Coronavirus: Insight into the Humoral Immunity of SARS. Clin. Chem.
51: 1382-1396
[Abstract][Full Text]
Yu, F., Le, M. Q., Inoue, S., Thai, H. T. C., Hasebe, F., del Carmen Parquet, M., Morita, K.
(2005). Evaluation of Inapparent Nosocomial Severe Acute Respiratory Syndrome Coronavirus Infection in Vietnam by Use of Highly Specific Recombinant Truncated Nucleocapsid Protein-Based Enzyme-Linked Immunosorbent Assay. CVI
12: 848-854
[Abstract][Full Text]
Sui, J., Li, W., Roberts, A., Matthews, L. J., Murakami, A., Vogel, L., Wong, S. K., Subbarao, K., Farzan, M., Marasco, W. A.
(2005). Evaluation of Human Monoclonal Antibody 80R for Immunoprophylaxis of Severe Acute Respiratory Syndrome by an Animal Study, Epitope Mapping, and Analysis of Spike Variants. J. Virol.
79: 5900-5906
[Abstract][Full Text]
Wang, B., Potter, S. J., Lin, Y., Cunningham, A. L., Dwyer, D. E., Su, Y., Ma, X., Hou, Y., Saksena, N. K.
(2005). Rapid and Sensitive Detection of Severe Acute Respiratory Syndrome Coronavirus by Rolling Circle Amplification. J. Clin. Microbiol.
43: 2339-2344
[Abstract][Full Text]
van den Brink, E. N., ter Meulen, J., Cox, F., Jongeneelen, M. A. C., Thijsse, A., Throsby, M., Marissen, W. E., Rood, P. M. L., Bakker, A. B. H., Gelderblom, H. R., Martina, B. E., Osterhaus, A. D. M. E., Preiser, W., Doerr, H. W., de Kruif, J., Goudsmit, J.
(2005). Molecular and Biological Characterization of Human Monoclonal Antibodies Binding to the Spike and Nucleocapsid Proteins of Severe Acute Respiratory Syndrome Coronavirus. J. Virol.
79: 1635-1644
[Abstract][Full Text]
He, Y., Zhou, Y., Wu, H., Luo, B., Chen, J., Li, W., Jiang, S.
(2004). Identification of Immunodominant Sites on the Spike Protein of Severe Acute Respiratory Syndrome (SARS) Coronavirus: Implication for Developing SARS Diagnostics and Vaccines. J. Immunol.
173: 4050-4057
[Abstract][Full Text]
Woo, P. C. Y., Lau, S. K. P., Wong, B. H. L., Chan, K.-h., Chu, C.-m., Tsoi, H.-w., Huang, Y., Peiris, J. S. M., Yuen, K.-y.
(2004). Longitudinal Profile of Immunoglobulin G (IgG), IgM, and IgA Antibodies against the Severe Acute Respiratory Syndrome (SARS) Coronavirus Nucleocapsid Protein in Patients with Pneumonia Due to the SARS Coronavirus. CVI
11: 665-668
[Abstract][Full Text]
He, Z., Dong, Q., Zhuang, H., Song, S., Peng, G., Luo, G., Dwyer, D. E.
(2004). Kinetics of Severe Acute Respiratory Syndrome (SARS) Coronavirus-Specific Antibodies in 271 Laboratory-Confirmed Cases of SARS. CVI
11: 792-794
[Abstract][Full Text]
Wang, B., Chen, H., Jiang, X., Zhang, M., Wan, T., Li, N., Zhou, X., Wu, Y., Yang, F., Yu, Y., Wang, X., Yang, R., Cao, X.
(2004). Identification of an HLA-A*0201-restricted CD8+ T-cell epitope SSp-1 of SARS-CoV spike protein. Blood
104: 200-206
[Abstract][Full Text]
Chen, W., Xu, Z., Mu, J., Yang, L., Gan, H., Mu, F., Fan, B., He, B., Huang, S., You, B., Yang, Y., Tang, X., Qiu, L., Qiu, Y., Wen, J., Fang, J., Wang, J.
(2004). Antibody response and viraemia during the course of severe acute respiratory syndrome (SARS)-associated coronavirus infection. J Med Microbiol
53: 435-438
[Abstract][Full Text]
Lu, L., Manopo, I., Leung, B. P., Chng, H. H., Ling, A. E., Chee, L. L., Ooi, E. E., Chan, S.-W., Kwang, J.
(2004). Immunological Characterization of the Spike Protein of the Severe Acute Respiratory Syndrome Coronavirus. J. Clin. Microbiol.
42: 1570-1576
[Abstract][Full Text]
Tan, Y.-J., Goh, P.-Y., Fielding, B. C., Shen, S., Chou, C.-F., Fu, J.-L., Leong, H. N., Leo, Y. S., Ooi, E. E., Ling, A. E., Lim, S. G., Hong, W.
(2004). Profiles of Antibody Responses against Severe Acute Respiratory Syndrome Coronavirus Recombinant Proteins and Their Potential Use as Diagnostic Markers. CVI
11: 362-371
[Abstract][Full Text]
He, Q., Chong, K. H., Chng, H. H., Leung, B., Ling, A. E., Wei, T., Chan, S.-W., Ooi, E. E., Kwang, J.
(2004). Development of a Western Blot Assay for Detection of Antibodies against Coronavirus Causing Severe Acute Respiratory Syndrome. CVI
11: 417-422
[Abstract][Full Text]
Sui, J., Li, W., Murakami, A., Tamin, A., Matthews, L. J., Wong, S. K., Moore, M. J., Tallarico, A. St. C., Olurinde, M., Choe, H., Anderson, L. J., Bellini, W. J., Farzan, M., Marasco, W. A.
(2004). Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association. Proc. Natl. Acad. Sci. USA
101: 2536-2541
[Abstract][Full Text]