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Volume 349:519-521 August 7, 2003 Number 6
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From Presumed Benefit to Potential Harm — Hormone Therapy and Heart Disease
David M. Herrington, M.D., M.H.S., and Timothy D. Howard, Ph.D.

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-Related Article
 by Manson, J. E.
-Related Article
 by Hodis, H. N.
-PubMed Citation
During the past decade, postmenopausal hormone therapy became one of the most frequently prescribed therapies in the United States, with a highly diversified portfolio of presumed benefits for postmenopausal women. The belief that hormone therapy might reduce a woman's risk of coronary heart disease contributed considerably to its widespread use. Beginning in 1998, results from a series of randomized clinical trials, including new data presented in this issue of the Journal by Manson et al. (pages 523–534) and Hodis et al. (pages 535–545), have clearly demonstrated that hormone therapy does not slow the clinical or anatomical progression of established coronary . . . [Full Text of this Article]


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From the Departments of Internal Medicine/Cardiology (D.M.H.) and Pediatrics (T.D.H.), Wake Forest University School of Medicine, Winston-Salem, N.C.


Related Letters:

Hormone Therapy and Cardiovascular Disease
Kannel W. B., Levy D., Sullivan J. L., Bailar J. C. III
Extract | Full Text | PDF  
N Engl J Med 2003; 349:2075-2076, Nov 20, 2003. Correspondence

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