During the past decade, postmenopausal hormone therapy becameone of the most frequently prescribed therapies in the UnitedStates, with a highly diversified portfolio of presumed benefitsfor postmenopausal women. The belief that hormone therapy mightreduce a woman's risk of coronary heart disease contributedconsiderably to its widespread use. Beginning in 1998, resultsfrom a series of randomized clinical trials, including new datapresented in this issue of the Journal by Manson et al. (pages523534) and Hodis et al. (pages 535545), haveclearly demonstrated that hormone therapy does not slow theclinical or anatomical progression of established coronary . . . [Full Text of this Article]
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From the Departments of Internal Medicine/Cardiology (D.M.H.) and Pediatrics (T.D.H.), Wake Forest University School of Medicine, Winston-Salem, N.C.
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