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Previous Volume 349:570-582 August 7, 2003 Number 6 Next

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Adult human stem cells that are intrinsic to various tissues have been described and characterized, some of them only recently. These cells are capable of maintaining, generating, and replacing terminally differentiated cells within their own specific tissue as a consequence of physiologic cell turnover or tissue damage due to injury.¹ Hematopoietic stem cells that give rise to blood cells and move between bone marrow and peripheral blood are the best-characterized adult stem cells in humans. Recent data suggest that adult stem cells generate differentiated cells beyond their own tissue boundaries, a process termed "developmental plasticity." In this review we focus . . . [Full Text of this Article]

Adult Stem Cells and Their Potential for Developmental Plasticity

Preclinical in Vivo Studies

Adult Stem Cells Derived from Bone Marrow

Adult Stem Cells Derived from Peripheral Blood

Clinical in Vivo Studies

Adult Stem Cells Derived from Bone Marrow and Peripheral Blood

Limitations in Identifying Chimeric Cells

Reports That Question Developmental Plasticity

Cell Fusion

Models of Differentiation of Adult Stem Cells into Solid-Organ–Specific Cells

Potential Role of Circulating Adult Stem Cells in Tissue Repair

Mechanisms of Stem-Cell Recruitment and Differentiation

A Clinical Model of Solid-Organ Tissue Generated by Circulating Stem Cells

Potential Clinical Applications

Embryonic Stem Cells

Conclusions and Outlook

Source Information

From the Department of Blood and Marrow Transplantation (M.K.) and the Department of Bioimmunotherapy (Z.E.), the University of Texas M.D. Anderson Cancer Center, Houston.

Address reprint requests to Dr. Körbling at the University of Texas M.D. Anderson Cancer Center, Department of Blood and Marrow Transplantation, Unit 423, 1515 Holcombe Blvd., Houston, TX 77030, or at mkorblin@mdanderson.org.

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