The technique of the sentinel-node biopsy has reoriented ourunderstanding of the dynamics between a solid tumor and itsassociated lymphatic collection system.1,2,3,4 Moreover, thesentinel-node biopsy is an excellent way of lessening the sideeffects of surgery and of improving the accuracy of regionalnode resection. Since this method is such a fundamental changein surgical oncology, it is important to design clinical trialsthat will give a clear answer to the following question: Isa reduction in survival the price of limited and more accuratesurgery?
The design of a clinical trial starts not with a formal application. . . [Full Text of this Article]
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From the Departments of Surgery (D.K.) and Medical Biostatistics (T.A.), Vermont Cancer Center, University of Vermont College of Medicine, Burlington.
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Sentinel-Node Biopsy in Breast Cancer
Badwe R. A., Thorat M. A., Parmar V. V., De Salvo G. L., Del Bianco P., Zavagno G., Munster A. M., McMasters K. M., Veronesi U., Maisonneuve P., Krag D., Ashikaga T.
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N Engl J Med 2003;
349:1968-1971, Nov 13, 2003.
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