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Volume 349:714-716 August 14, 2003 Number 7
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The Conjugate Vaccine and Invasive Pneumococcal Disease

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 by Whitney, C. G.
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To the Editor: Whitney and colleagues (May 1 issue)1 observed, among adults, a decline in the rates of invasive pneumococcal disease caused by 7-valent conjugate serotypes but not by nonconjugate vaccine serotypes. They cautiously suggest that vaccination of children may be exerting a population effect. Adults in households with young children have high rates of nasopharyngeal carriage of Streptococcus pneumoniae,2 and Whitney et al. found a strong correlation between the magnitude of the decline in the incidence of disease among children less than 2 years of age and that among adults 20 to 39 years of age. However, adults 65 . . . [Full Text of this Article]




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