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Previous Volume 349:753-759 August 21, 2003 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Perspective by Kaiser, U. B. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

Spontaneous ovarian hyperstimulation syndrome is a rare event, in contrast to iatrogenic ovarian hyperstimulation syndrome, which is induced with the use of gonadotropins in assisted reproductive medicine. The pathological features of the syndrome, whether spontaneous or iatrogenic, include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis.¹ The pathogenesis of the syndrome and its systemic manifestations are poorly understood.^2,3,4,5,6 We describe a familial case of recurrent spontaneous ovarian hyperstimulation syndrome. The affected women were heterozygous for a mutation in the transmembrane domain of the gene encoding the follicle-stimulating hormone receptor. In . . . [Full Text of this Article]

Case Report

Family History

Methods

Hormone Assays

DNA Sequencing

Construction of an Expression Vector Encoding the Mutated Follicle-Stimulating Hormone Receptor

Functional Studies of the Mutated Receptor

Results

Identification of the Mutation

Functional Studies of the Mutant Receptor

Discussion

Source Information

From the Service de Gynécologie Obstétrique (C.V., C.G., L.P., S.C., P.D.), INSERM EMI Unité 0018 (P.R., F.S.), Service d'Endocrinologie (P.R.), Laboratoire de Biochimie (F.S.), Laboratoire d'Anatomopathologie (A.C.), and Laboratoire d'Hormonologie (E.M.), Centre Hospitalier Universitaire d'Angers, Angers; INSERM EMI Unité 120, Hôpital Bicêtre, Le Kremlin Bicêtre (I.B., A.D., M.M.); and Laboratoire d'Hormonologie, Hôpital St. Vincent de Paul, Paris (N.L.) — all in France.

Address reprint requests to Dr. Rodien at the Service d'Endocrinologie, Centre Hospitalier Universitaire d'Angers, 4, rue Larrey, 49033 Angers CEDEX 01, France, or at parodien@chu-angers.fr.

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