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Volume 349:827-828 August 28, 2003 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Not unlike its human host, the human immunodeficiency virus (HIV) is often unfaithful while reproducing. Copies made are not completely true to the original; a mistake occurs about once every 10,000 nucleotides. This may not seem like much, until we remember the enormous production rate of the virus, which guarantees that every possible mutation will arise at each position of the genome every day. Errors in reproduction, as well as recombination between the two RNA genomes, drive the diversification of HIV into quasi-species and strains.

Antiretroviral treatment has diverse effects, including selection for mutants with decreased drug sensitivity that progressively . . . [Full Text of this Article]

Source Information

From the Division of Infectious Diseases, Hôpital Cantonal Universitaire, Geneva.

Related Letters:

Structured Treatment Interruption for Patients with Human Immunodeficiency Virus Infection
Roca B., Agut H., Lawrence J., Hullsiek K. H., Baxter J. D., Hirschel B.
Extract | Full Text | PDF  
N Engl J Med 2003; 349:2268-2269, Dec 4, 2003. Correspondence

This article has been cited by other articles:

• Roca, B., Agut, H., Lawrence, J., Hullsiek, K. H., Baxter, J. D., Hirschel, B. (2003). Structured Treatment Interruption for Patients with Human Immunodeficiency Virus Infection. NEJM 349: 2268-2269 [Full Text]