During the 20th century, enormous progress was made in improvingthe health and therefore the life span of all Americans. Theaverage life expectancy at birth increased by nearly 30 yearsbetween 1900 and 2000. Although the largest gains were madein the early part of the century, we still managed to add another1.5 years between 1990 and 2000.
Much of our continued success in extending life expectancy overthe past several decades is almost certainly due to researchsupported by the National Institutes of Health (NIH) and . . . [Full Text of this Article]
Where is the Problem?
The Physician and Translation
Patients' Behavior
Intervention by Physicians to Keep Patients on the Road
Closing the Loop
Source Information
From the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md., and the Department of Health and Human Services, Washington, D.C.
Address reprint requests to Dr. Lenfant at the National Heart, Lung, and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bldg. 31, Room 5A52, Bethesda, MD 20892.
Rosemann, T, Laux, G, Szecsenyi, J, Grol, R
(2008). The Chronic Care Model: congruency and predictors among primary care patients with osteoarthritis. Qual Saf Health Care
17: 442-446
[Abstract][Full Text]
Tu, J. V. MD PhD, Khalid, L. MD, Donovan, L. R. BScN MBA, Ko, D. T. MD MSc, for the Canadian Cardiovascular Outcomes Research,
(2008). Indicators of quality of care for patients with acute myocardial infarction. CMAJ
179: 909-915
[Abstract][Full Text]
Pronovost, P. J, Berenholtz, S. M, Needham, D. M
(2008). Translating evidence into practice: a model for large scale knowledge translation. BMJ
337: a1714-a1714
[Full Text]
Planas, L. G.
(2008). Intervention design, implementation, and evaluation. Am J Health Syst Pharm
65: 1854-1863
[Abstract][Full Text]
Kottke, T. E., Solberg, L. I., Nelson, A. F., Belcher, D. W., Caplan, W., Green, L. W., Lydick, E., Magid, D. J., Rolnick, S. J., Woolf, S. H.
(2008). Optimizing Practice Through Research: A New Perspective to Solve an Old Problem. Ann Fam Med
6: 459-462
[Abstract][Full Text]
McAlister, F. A.
(2008). Cardiac Resynchronization Therapy for Heart Failure: A Hammer in Search of Nails. Circulation
118: 901-903
[Full Text]
Mold, J. W., Aspy, C. A., Nagykaldi, Z.
(2008). Implementation of Evidence-Based Preventive Services Delivery Processes in Primary Care: An Oklahoma Physicians Resource/Research Network (OKPRN) Study. J Am Board Fam Med
21: 334-344
[Abstract][Full Text]
Norris, K., Nissenson, A. R.
(2008). Race, Gender, and Socioeconomic Disparities in CKD in the United States. J. Am. Soc. Nephrol.
19: 1261-1270
[Abstract][Full Text]
Quon, B. S., Gan, W. Q., Sin, D. D.
(2008). Contemporary Management of Acute Exacerbations of COPD: A Systematic Review and Metaanalysis. Chest
133: 756-766
[Abstract][Full Text]
Cheng, T. L., Cohn, R. D., Dover, G. J.
(2008). The Genetics Revolution and Primary Care Pediatrics. JAMA
299: 451-453
[Full Text]
van Wyk, J. T., van Wijk, M. A.M., Sturkenboom, M. C.J.M., Mosseveld, M., Moorman, P. W., van der Lei, J.
(2008). Electronic Alerts Versus On-Demand Decision Support to Improve Dyslipidemia Treatment: A Cluster Randomized Controlled Trial. Circulation
117: 371-378
[Abstract][Full Text]
Esteban, A., Ferguson, N. D., Meade, M. O., Frutos-Vivar, F., Apezteguia, C., Brochard, L., Raymondos, K., Nin, N., Hurtado, J., Tomicic, V., Gonzalez, M., Elizalde, J., Nightingale, P., Abroug, F., Pelosi, P., Arabi, Y., Moreno, R., Jibaja, M., D'Empaire, G., Sandi, F., Matamis, D., Montanez, A. M., Anzueto, A., for the VENTILA Group,
(2008). Evolution of Mechanical Ventilation in Response to Clinical Research. Am. J. Respir. Crit. Care Med.
177: 170-177
[Abstract][Full Text]
Gilbert, G. H., Williams, O. D., Rindal, D. B., Pihlstrom, D. J., Benjamin, P. L., Wallace, M. C., for the DPBRN Collaborative Group,
(2008). The Creation and Development of the Dental Practice-Based Research Network. Journal of the American Dental Association
139: 74-81
[Abstract][Full Text]
Kotchen, T. A.
(2007). Why the Slow Diffusion of Treatment Guidelines Into Clinical Practice?. Arch Intern Med
167: 2394-2395
[Full Text]
Klenk, J., Rapp, K., Buchele, G., Keil, U., Weiland, S. K.
(2007). Increasing life expectancy in Germany: quantitative contributions from changes in age- and disease-specific mortality. Eur J Public Health
17: 587-592
[Abstract][Full Text]
Kuller, L.
(2007). Is Phenomenology the Best Approach to Health Research?. Am J Epidemiol
166: 1109-1115
[Abstract][Full Text]
Lumbreras, B., Porta, M., Hernandez-Aguado, I.
(2007). Assessing the social meaning, value and implications of research in genomics. J. Epidemiol. Community Health
61: 755-756
[Full Text]
Khoury, M. J., Gwinn, M., Bowen, M. S.
(2007). Genomics and Public Health Research. JAMA
297: 2347-2347
[Full Text]
Pawlson, L. G.
(2007). Health Information Technology: Does It Facilitate Or Hinder Rapid Learning?. Health Aff (Millwood)
26: w178-w180
[Abstract][Full Text]
Binns, H. J., Lanier, D., Pace, W. D., Galliher, J. M., Ganiats, T. G., Grey, M., Ariza, A. J., Williams, R., for the Primary Care Network Survey (PRINS) Partic,
(2007). Describing Primary Care Encounters: The Primary Care Network Survey and the National Ambulatory Medical Care Survey. Ann Fam Med
5: 39-47
[Abstract][Full Text]
Choudhry, N. K., Avorn, J., Antman, E. M., Schneeweiss, S., Shrank, W. H.
(2007). Should Patients Receive Secondary Prevention Medications For Free After A Myocardial Infarction? An Economic Analysis. Health Aff (Millwood)
26: 186-194
[Abstract][Full Text]
Schuster, R. J., Terwoord, N. A., Tasosa, J.
(2006). Changing physician practice behavior to measure and improve clinical outcomes.. American Journal of Medical Quality
21: 394-400
[Abstract]
Aberegg, S. K., Arkes, H., Terry, P. B.
(2006). Failure to Adopt Beneficial Therapies Caused by Bias in Medical Evidence Evaluation. Med Decis Making
26: 575-582
[Abstract]
Haenggi, M., Ypparila, H., Hauser, K., Caviezel, C., Korhonen, I., Takala, J., Jakob, S. M.
(2006). The Effects of Dexmedetomidine/Remifentanil and Midazolam/Remifentanil on Auditory-Evoked Potentials and Electroencephalogram at Light-to-Moderate Sedation Levels in Healthy Subjects. Anesth. Analg.
103: 1163-1169
[Abstract][Full Text]
Glasgow, R. E., Klesges, L. M., Dzewaltowski, D. A., Estabrooks, P. A., Vogt, T. M.
(2006). Evaluating the impact of health promotion programs: using the RE-AIM framework to form summary measures for decision making involving complex issues. Health Educ Res
21: 688-694
[Abstract][Full Text]
Mandelzweig, L., Battler, A., Boyko, V., Bueno, H., Danchin, N., Filippatos, G., Gitt, A., Hasdai, D., Hasin, Y., Marrugat, J., Van de Werf, F., Wallentin, L., Behar, S., on behalf of the Euro Heart Survey Investigators,
(2006). The second Euro Heart Survey on acute coronary syndromes: characteristics, treatment, and outcome of patients with ACS in Europe and the Mediterranean Basin in 2004. Eur Heart J
27: 2285-2293
[Abstract][Full Text]
Heuschmann, P. U., Biegler, M. K., Busse, O., Elsner, S., Grau, A., Hasenbein, U., Hermanek, P., Janzen, R. W.C., Kolominsky-Rabas, P. L., Kraywinkel, K., Lowitzsch, K., Misselwitz, B., Nabavi, D. G., Otten, K., Pientka, L., von Reutern, G. M., Ringelstein, E. B., Sander, D., Wagner, M., Berger, K.
(2006). Development and Implementation of Evidence-Based Indicators for Measuring Quality of Acute Stroke Care: The Quality Indicator Board of the German Stroke Registers Study Group (ADSR). Stroke
37: 2573-2551
[Abstract][Full Text]
Kotchen, T. A.
(2006). From Clinical Trials to Clinical Practice: Why the Gap?. Hypertension
48: 196-197
[Full Text]
Klesges, R. C., Johnson, K. C., Somes, G.
(2006). Varenicline for smoking cessation: definite promise, but no panacea.. JAMA
296: 94-95
[Full Text]
Leeman, J.
(2006). Interventions to Improve Diabetes Self-management: Utility and Relevance for Practice.. The Diabetes Educator
32: 571-583
[Abstract][Full Text]
Riehl, C.
(2006). Feeling Better: A Comparison of Medical Research and Education Research. EDUCATIONAL RESEARCHER
35: 24-29
[Abstract]
Thamlikitkul, V., Indranoi, A.
(2006). Switching from heparinized saline flush to normal saline flush for maintaining peripheral venous catheter patency.. Int J Qual Health Care
18: 183-185
[Abstract][Full Text]
Touze, E., Saillour-Glenisson, F., Durieux, P., Verdier, A., Leyshon, S., Bendavid, S., Attard, T., Scheimann, A., Mas, J. L., Coste, J.
(2006). Lack of validity of a French adaptation of a scale measuring attitudes towards clinical practice guidelines. Int J Qual Health Care
18: 195-202
[Abstract][Full Text]
Brown, R. T.
(2006). Editorial: Pediatric Psychology and the National Institutes of Health. J Pediatr Psychol
31: 227-232
[Full Text]
Rauchhaus, M., Doehner, W., Anker, S. D.
(2006). Heart failure therapy: testosterone replacement and its implications. Eur Heart J
27: 10-12
[Full Text]
Green, L. A., Seifert, C. M.
(2005). Translation of Research Into Practice: Why We Can't "Just Do It". J Am Board Fam Med
18: 541-545
[Abstract][Full Text]
van Wyk, J. T., van Wijk, M. A.M., Sturkenboom, M. C.J.M., Moorman, P. W., van der Lei, J.
(2005). Identification of the Four Conventional Cardiovascular Disease Risk Factors by Dutch General Practitioners. Chest
128: 2521-2527
[Abstract][Full Text]
Blackburn, G. L
(2005). Teaching, learning, doing: best practices in education. Am. J. Clin. Nutr.
82: 218S-221S
[Abstract][Full Text]
Mulshine, J. L.
(2005). Clinical Issues in the Management of Early Lung Cancer. Clin. Cancer Res.
11: 4993s-4998s
[Abstract][Full Text]
Mulshine, J. L., Sullivan, D. C.
(2005). Lung Cancer Screening. NEJM
352: 2714-2720
[Full Text]
Osser, D. N., Patterson, R. D., Levitt, J. J.
(2005). Guidelines, Algorithms, and Evidence-Based Psychopharmacology Training for Psychiatric Residents. Acad. Psychiatry
29: 180-186
[Abstract][Full Text]
Truog, W. E.
(2005). Chronic Lung Disease and Randomized Interventional Trials: Status in 2005. NeoReviews
6: e278-e288
[Full Text]
Wilkinson, G. R.
(2005). Drug Metabolism and Variability among Patients in Drug Response. NEJM
352: 2211-2221
[Full Text]
Mulshine, J. L.
(2005). New Developments in Lung Cancer Screening. JCO
23: 3198-3202
[Abstract][Full Text]
Mold, J. W., Peterson, K. A.
(2005). Primary Care Practice-Based Research Networks: Working at the Interface Between Research and Quality Improvement. Ann Fam Med
3: S12-S20
[Abstract][Full Text]
Schwartz, M. D., Basco, W. T. Jr, Grey, M. R., Elmore, J. G., Rubenstein, A.
(2005). Rekindling Student Interest in Generalist Careers. ANN INTERN MED
142: 715-724
[Abstract][Full Text]
Guzelian, P. S, Victoroff, M. S, Halmes, N C., James, R. C, Guzelian, C. P
(2005). Evidence-based toxicology: a comprehensive framework for causation. Hum Exp Toxicol
24: 161-201
[Abstract]
Rickles, F. R.
(2005). Thrombolytic (fibrinolytic) drugs and progress in treating cardiovascular disease. FASEB J.
19: 671-671
[Full Text]
Koren, M. J., Hunninghake, D. B., the ALLIANCE Investigators,
(2004). Clinical outcomes in managed-care patients with coronary heart disease treated aggressively in lipid-lowering disease management clinics: The alliance study. J Am Coll Cardiol
44: 1772-1779
[Abstract][Full Text]
Reilly, B. M
(2004). The essence of EBM. BMJ
329: 991-992
[Full Text]
Califf, R. M., Nissen, S. E., DeMaria, A. N., Ohman, E. M., Pitt, B., Willerson, J. T., Bilheimer, D. W., Cohn, J. N., Feigal, D. W. Jr, Hampson, L., Lorell, B. H., Pepine, C. J., Popp, R. L.
(2004). Task force 2: Investigator participation in clinical research. J Am Coll Cardiol
44: 1729-1736
[Full Text]
Califf, R. M., Nissen, S. E., DeMaria, A. N., Ohman, E. M., Pitt, B., Willerson, J. T., Bilheimer, D. W., Cohn, J. N., Feigal, D. W. Jr, Hampson, L., Lorell, B. H., Pepine, C. J., Popp, R. L.
(2004). Task Force 2: Investigator Participation in Clinical Research. Circulation
110: 2517-2524
[Full Text]
Ornstein, S., Jenkins, R. G., Nietert, P. J., Feifer, C., Roylance, L. F., Nemeth, L., Corley, S., Dickerson, L., Bradford, W. D., Litvin, C.
(2004). A Multimethod Quality Improvement Intervention To Improve Preventive Cardiovascular Care: A Cluster Randomized Trial. ANN INTERN MED
141: 523-532
[Abstract][Full Text]
Khoury, M. J, Millikan, R., Little, J., Gwinn, M.
(2004). The emergence of epidemiology in the genomics age. Int J Epidemiol
33: 936-944
[Full Text]
Silliman, R. A.
(2004). Crossing the Quality Chasm in Breast Cancer Care. JCO
22: 3654-3656
[Full Text]
Hlatky, M. A.
(2004). Underuse of Evidence-Based Therapies. Circulation
110: 644-645
[Full Text]
Gaspoz, J.-M.
(2004). Quality of in-hospital care in acute coronary syndromes: it is time to close the gap. Int J Qual Health Care
16: 273-274
[Full Text]
Pieske, B.
(2004). Reverse remodeling in heart failure - fact or fiction?. Eur Heart J Suppl
6: D66-D78
[Abstract][Full Text]
Maizlish, N. A., Shaw, B., Hendry, K.
(2004). Glycemic Control in Diabetic Patients Served by Community Health Centers. American Journal of Medical Quality
19: 172-179
[Abstract]
Pronovost, P. J., Wu, A. W., Sexton, J. B.
(2004). Acute Decompensation after Removing a Central Line: Practical Approaches to Increasing Safety in the Intensive Care Unit. ANN INTERN MED
140: 1025-1033
[Abstract][Full Text]
Centers for Disease Control and Prevention Primary,
(2004). Primary Prevention of Type 2 Diabetes Mellitus by Lifestyle Intervention: Implications for Health Policy. ANN INTERN MED
140: 951-957
[Abstract][Full Text]
Larson, E. B., the Society of General Internal Medicine (SGIM) Ta,
(2004). Health Care System Chaos Should Spur Innovation: Summary of a Report of the Society of General Internal Medicine Task Force on the Domain of General Internal Medicine. ANN INTERN MED
140: 639-643
[Abstract][Full Text]
Humphrey, H. J.
(2004). Customizing Residency Education. ANN INTERN MED
140: 663-664
[Full Text]
Crowley, W. F. Jr, Sherwood, L., Salber, P., Scheinberg, D., Slavkin, H., Tilson, H., Reece, E. A., Catanese, V., Johnson, S. B., Dobs, A., Genel, M., Korn, A., Reame, N., Bonow, R., Grebb, J., Rimoin, D.
(2004). Clinical Research in the United States at a Crossroads: Proposal for a Novel Public-Private Partnership to Establish a National Clinical Research Enterprise. JAMA
291: 1120-1126
[Abstract][Full Text]
Bonow, R. O., Smith, S. C. Jr
(2004). Cardiovascular Manpower: The Looming Crisis. Circulation
109: 817-820
[Full Text]
Macklem, P. T.
(2004). Con: Greater Funding of Cell and Molecular Biology Has Not Delivered What Was Promised to Respiratory Medicine. Am. J. Respir. Crit. Care Med.
169: 438-439
[Full Text]
Grant, A. O., Jacobs, A. K., Clancy, C.
(2004). Cardiovascular Disease in Women: Are There Solutions?. Circulation
109: 561-561
[Full Text]
Drazen, J. M., Ingelfinger, J. R.
(2003). Grants, Politics, and the NIH. NEJM
349: 2259-2261
[Full Text]
O'Malley, P. G., Pluhar, W. M., Gandjour, A.
(2003). Lost in Translation. NEJM
349: 2273-2274
[Full Text]
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