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Volume 349:906-908 August 28, 2003 Number 9
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Regression of Microalbuminuria in Type 1 Diabetes

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by Ritz, E.
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by Perkins, B. A.
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To the Editor: In their meticulous study of type 1 diabetes (June 5 issue), Perkins et al.1 overlook dietary protein intake as a potentially important determinant of fluctuations in urinary albumin excretion over time. Dietary protein intake has been positively associated with increased urinary albumin excretion in diabetic2 and nondiabetic3 populations. Consistent with these observations is the finding that a protein load induces an increase in urinary albumin excretion in healthy persons with a single kidney.4 The mechanism by which this process occurs is not well understood, but it may be related to alterations in the permeability of the glomerular . . . [Full Text of this Article]



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