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Correction to Campagna et al., N Engl J Med 348(21):2110-2124 May 22, 2003.

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Volume 349:909-910 August 28, 2003 Number 9
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Mechanisms of Actions of Inhaled Anesthetics

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 by Campagna, J. A.
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To the Editor: Campagna et al. (May 22 issue)1 provide a comprehensive review of the mechanisms of actions of inhaled anesthetics. I was surprised, however, by some of the information they provide in Table 2 of their article. First, the authors suggest that the channels coupled to ionotropic glutamate receptors are permeable to calcium and magnesium. However, these channels are permeable only to calcium and monovalent cations, especially in the case of N-methyl-D-aspartate (NMDA) receptors. Magnesium actually blocks NMDA channels in a voltage-dependent manner,2 a characteristic that is the basis for its use as a noncompetitive NMDA antagonist in . . . [Full Text of this Article]




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