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Previous Volume 349:910-911 August 28, 2003 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In Figure 1 of their article, Wooster and Weber (June 5 issue)¹ ignore an important paradox by dismissing mutations in the ATM (ataxia–telangiectasia mutated) gene as not contributing to breast cancer. Current theories propose that ATM senses DNA damage and then signals BRCA1. For example, ATM phosphorylates BRCA1, signaling it to arrest the cell cycle after DNA damage due to ionizing radiation. Pathogenic BRCA1 mutations markedly increase the risk of breast cancer. The dependence of BRCA1 on ATM thus makes it logical that mutations in the ATM gene would also increase the risk of breast cancer. Similarly, . . . [Full Text of this Article]

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