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Previous Volume 350:4-7 January 1, 2004 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Eicosanoids are lipid mediators of inflammation; they include a variety of compounds (prostaglandins, thromboxanes, leukotrienes, hydroxy- and epoxy-fatty acids, lipoxins, and isoprostanes) that are derived from the ubiquitous 20-carbon atom arachidonate (20 in Greek is "eicosa") and a few similar polyunsaturated fatty acids. These fatty acids are esterified in the phospholipids of biologic membranes and then released in response to a variety of stimuli to become substrates for metabolizing enzymes. More than 20 years ago, Samuelsson and coworkers identified leukotrienes as a class of eicosanoids that are derived through the action of 5-lipoxygenase. This enzyme, which is selectively expressed in . . . [Full Text of this Article]

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From the Division of Cardiology and the Center of Excellence on Aging, Gabriele d'Annunzio University, Chieti (R.D.C.); and the Laboratory for Thrombosis and Vascular Research, Institute of Clinical Physiology, National Research Council, Pisa (R.D.C., A.Z.) — both in Italy.

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