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Volume 350:1053-1054 March 4, 2004 Number 10
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Comparison of Regimens as Initial Therapy for HIV

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 by Skolnik, P. R.
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 by Robbins, G. K.
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To the Editor: Skolnik (Dec. 11 issue),1 in his editorial accompanying the report by Robbins et al.2 on initial therapy for human immunodeficiency virus (HIV) infection, suggests that nelfinavir, which was a component of the antiretroviral regimens used in the study by Robbins et al., may be less effective than other protease inhibitors for the initiation of HIV treatment. However, there was no meaningful difference between efavirenz and nelfinavir when combined with stavudine and didanosine. Moreover, after a median of 2.3 years, the percentage of successfully treated patients who started to take nelfinavir or efavirenz was virtually identical: nelfinavir, 170 . . . [Full Text of this Article]




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