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Volume 350:1058 March 4, 2004 Number 10
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Case 36-2003: A Woman with Impaired Renal Function

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by Singh, A. K.
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To the Editor: In Case 36-2003 (Nov. 20 issue),1 Singh and Bazari suggest that for patients with presumptive drug-induced acute interstitial nephritis, initiation of corticosteroid therapy should be "straightforward" and that the response of renal function to high-dose corticosteroids should be considered in the decision whether or not to perform a kidney biopsy. However, the rationale for treating drug-induced acute interstitial nephritis with corticosteroids remains unsubstantiated. The results of seven selected studies failed to provide evidence of a beneficial effect of corticosteroid therapy in terms of preventing chronic renal insufficiency in patients with this problem.2

Furthermore, other findings indicate that . . . [Full Text of this Article]



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