GB virus C (GBV-C), an RNA virus in the Flaviviridae family,is a close relative of the hepatitis C virus. Although it hasbeen shown that many people worldwide are infected with thisvirus, no clear association between the virus and a known diseasestate has been demonstrated. GBV-C has been shown to replicatein human peripheral-blood mononuclear cells in vitro, and itcommonly coinfects patients with human immunodeficiency virus(HIV). GBV-C is transmitted through predominantly parenteralroutes and has a high seroprevalence among intravenous-drugusers. Nonetheless, the sexual transmission of GBV-C has alsobeen demonstrated recently. Infection with or . . . [Full Text of this Article]
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From the Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Thomas Jefferson University, Philadelphia.
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