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Previous Volume 350:1118-1129 March 11, 2004 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In the past 10 years, remarkable strides have been made in the understanding of the natural history and pathogenesis of hepatitis B virus (HBV) infection. In this article we will review these advances, with particular reference to the implications for antiviral therapy.

History

Clinical and epidemiologic studies began to differentiate among various types of acute hepatitis in the decades after World War II. The groundbreaking studies of Krugman and colleagues in 1967 firmly established the existence of at least two types of hepatitis,¹ one of which (then called serum hepatitis, and now called hepatitis B) was parenterally transmitted. Links to the . . . [Full Text of this Article]

Virologic Features

Classification and Structure

Viral Genes and Proteins

Viral Replication Cycle

Pathogenesis of Hepatitis B

Natural History

            Primary Infection

            Persistent Infection

            Hepatocellular Carcinoma

Implications for Therapy

Interferon

Antiviral Drugs

            Lamivudine

            Other Nucleotide Analogues

Liver Transplantation

Source Information

From the Departments of Microbiology and Immunology and Medicine and the Howard Hughes Medical Institute, University of California, San Francisco (D.G.); and the Laboratory of Virology, Lindsley F. Kimball Research Institute, New York Blood Center, and the Department of Pathology, New York University School of Medicine — both in New York (A.M.P.).

Address reprint requests to Dr. Prince at the Laboratory of Virology, Lindsley F. Kimball Research Institute, New York Blood Center, 310 E. 67th St., New York, NY 10021, or at aprince@nybloodcenter.org.

Related Letters:

Hepatitis B
Janssen H. L.A., van Zonneveld M., Schalm S. W., Mohamadnejad M., Malekzadeh R.
Extract | Full Text | PDF  
N Engl J Med 2004; 350:2719-2720, Jun 24, 2004. Correspondence

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