Surgical therapy currently offers the only potential cure forpancreatic adenocarcinoma. Surgical morbidity and mortalityhave decreased dramatically in recent years; the perioperativemortality associated with pancreaticoduodenectomy in major centersis approximately 1 percent. However, only a few patients presentwith tumors that are amenable to resection, and even after resectionof a seemingly localized neoplasm, long-term survival is poor.1Since many medical centers now have the capacity to resect pancreaticcancer safely, it is increasingly important to identify effectivepostoperative (adjuvant) therapy if we are to achieve long-termsuccess in treating this disease.
Address reprint requests to Dr. Choti at Johns Hopkins Hospital, 600 N. Wolfe St., Halsted 614, Baltimore, MD 21287-5614, or at mchoti@jhmi.edu.
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