To the Editor: Quasispecies are known in RNA viruses such ashepatitis C virus and human immunodeficiency virus.1 Owing topoor fidelity of RNA polymerases, RNA-virus populations typicallycontain genetic variants that form a heterogeneous virus pool.The severe acute respiratory syndrome (SARS)associatedcoronavirus, as a newly identified RNA virus,2 however, hasbeen reported with relatively limited variations,3,4 and nopublished data have recorded the existence of quasispecies.
During the SARS outbreak from March to June in 2003, 132 patientswith SARS were treated in our unit, including those with thefirst cluster of cases in the Beijing, China, area.5. . . [Full Text of this Article]
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