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Previous Volume 350:1491-1494 April 8, 2004 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In the past decade, high-density lipoproteins (HDL) have emerged as a new potential therapeutic target for the treatment of cardiovascular disease. The key role of HDL as a carrier of excess cellular cholesterol in the reverse cholesterol transport pathway is believed to provide protection against atherosclerosis. In reverse cholesterol transport, peripheral tissues (e.g., vessel-wall macrophages) remove their excess cholesterol through the ATP-binding cassette transporter 1 (ABCA1) to poorly lipidated apolipoprotein A-I, forming pre--HDL. Lecithin–cholesterol acyltransferase then esterifies free cholesterol to cholesteryl esters, converting pre--HDL to mature spherical -HDL (see Figure).

View larger version (71K): [in this window] [in a new window]   Figure. Schematic Model of Reverse Cholesterol Transport . . . [Full Text of this Article]

 

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From the National Heart, Lung, and Blood Institute, Bethesda, Md.

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