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Correspondence
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Volume 350:1571-1575 April 8, 2004 Number 15
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Premature Coronary Disease in Systemic Lupus

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To the Editor: Roman et al.1 and Asanuma et al.2 (Dec. 18 issue) document accelerated development of atherosclerosis in patients with systemic lupus erythematosus (SLE), the implication being that atherosclerosis causes ischemic heart disease.3 Other causes of ischemic heart disease are possible, however. We recently observed two young women with corticosteroid-treated SLE who had intramyocardial vascular disease and myocardial infarction. The first patient was 20 years old and had a one-year history of SLE. Examination of the intramyocardial arteries showed extensive fibrinoid necrosis and thrombosis. There was no coronary-artery atherosclerosis. Extensive, biventricular acute myocardial infarction was the cause of death. . . . [Full Text of this Article]


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