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Previous Volume 350:1655-1664 April 15, 2004 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Bone metastases are a frequent complication of cancer, occurring in up to 70 percent of patients with advanced breast or prostate cancer¹ and in approximately 15 to 30 percent of patients with carcinoma of the lung, colon, stomach, bladder, uterus, rectum, thyroid, or kidney. The exact incidence of bone metastasis is unknown, but it is estimated that 350,000 people die with bone metastases annually in the United States.² Furthermore, once tumors metastasize to bone, they are usually incurable: only 20 percent of patients with breast cancer are still alive five years after the discovery of bone metastasis.³ The consequences of . . . [Full Text of this Article]

Types of Bone Metastasis

Bone as a Preferred Site of Metastasis

Control of Normal Bone Remodeling

Osteoclasts

Osteoblasts

Osteolytic Metastasis

Osteoblast Dysfunction in Myeloma

Osteolytic Metastasis from Breast Cancer — The Vicious Circle

Therapeutic Implications of Resorption and Tumor Growth

Osteoblastic Metastasis — Another Vicious Circle?

Osteoblastic Metastasis in Prostate Cancer

Biochemical Markers of Bone Turnover for the Detection of Bone Metastasis

Source Information

From the Department of Medicine, Division of Hematology–Oncology, University of Pittsburgh, the University of Pittsburgh Cancer Institute, and the Department of Veterans Affairs Medical Center — all in Pittsburgh.

Address reprint requests to Dr. Roodman at the University of Pittsburgh, School of Medicine/Hematology, Kaufmann Medical Bldg., Suite 601, 3471 5th Ave., Pittsburgh, PA 15213, or at roodmangd@msx.upmc.edu.

Related Letters:

Bone Metastasis
Hall F. M., Roodman G. D.
Extract | Full Text | PDF  
N Engl J Med 2004; 351:195-196, Jul 8, 2004. Correspondence

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