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Previous Volume 350:1970-1977 May 6, 2004 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors' clinical recommendations.

A 22-year-old woman presents to her gynecologist with genital lesions. Examination reveals bilateral labial ulcerations (Figure 1), cervical ulcerations, and mildly tender inguinal lymphadenopathy. To her knowledge, neither she nor any of the four sexual partners she has had, including her husband of two years, has ever had herpes. How should this patient's case be managed?

View larger version (77K): [in this window] [in a new window]   Figure 1. Genital Herpes Simplex Virus . . . [Full Text of this Article]

 
The Clinical Problem

Epidemiology

Natural History of Infection

            Initial Infection

            Recurrent Infection

            Neurologic Complications

            Neonatal HSV

            Human Immunodeficiency Virus Infection

Strategies and Evidence

Differential Diagnosis

Treatment

Psychological Effects of Genital Herpes

Screening

Areas of Uncertainty

Reducing the Risk of Transmission to a Seronegative Partner

Reducing Vertical Transmission of HSV Infection

HSV Vaccination

Resistant HSV Infections

Guidelines

Summary and Recommendations

Source Information

From the Departments of Pediatrics (D.W.K.) and Obstetrics and Gynecology (D.J.R.), University of Alabama at Birmingham, Birmingham.

Address reprint requests to Dr. Kimberlin at the Division of Pediatric Infectious Diseases, University of Alabama at Birmingham, 1600 Seventh Ave. S., CHB 303, Birmingham, AL 35233, or at dkimberlin@peds.uab.edu.

This article has been cited by other articles:

• Romanowski, B, Zdanowicz, Y M, Owens, S T (2008). In search of optimal genital herpes management and standard of care (INSIGHTS): doctors' and patients' perceptions of genital herpes. Sex. Transm. Infect. 84: 51-56 [Abstract] [Full Text]  
• Fuse, S., Bellfy, S., Yagita, H., Usherwood, E. J. (2007). CD8+ T Cell Dysfunction and Increase in Murine Gammaherpesvirus Latent Viral Burden in the Absence of 4-1BB Ligand. J. Immunol. 178: 5227-5236 [Abstract] [Full Text]  
• Xu, F., Sternberg, M. R., Kottiri, B. J., McQuillan, G. M., Lee, F. K., Nahmias, A. J., Berman, S. M., Markowitz, L. E. (2006). Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States.. JAMA 296: 964-973 [Abstract] [Full Text]  
• Ensor, D. (2005). The Significance of Herpes Simplex for School Nurses. The Journal of School Nursing 21: 10-16 [Abstract] [Full Text]