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Review Article
Medical Progress
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Volume 350:1978-1988 May 6, 2004 Number 19
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The Pathogenesis of Mycosis Fungoides
Michael Girardi, M.D., Peter W. Heald, M.D., and Lynn D. Wilson, M.D., M.P.H.

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Cutaneous T-cell lymphoma represents a complex array of disorders with various manifestations, clinical courses, and therapeutic considerations. Mycosis fungoides — in which the skin is variably affected by flat patches, thin plaques, or tumors — is the most common form of cutaneous T-cell lymphoma; consequently, more is understood about it from a basic immunologic and molecular perspective than is understood about the other variants. The related Sézary syndrome is a more aggressive form of cutaneous T-cell lymphoma in which the skin is diffusely affected and there is measurable involvement within the peripheral blood. In addition to mycosis fungoides and the . . . [Full Text of this Article]

Clinical Features

Skin-Homing Capacity of Malignant Cells

T-Cell Activation

Clonal Dominance of T Cells

Conclusions


Source Information

From the Departments of Dermatology (M.G., P.W.H., L.D.W.) and Therapeutic Radiology (L.D.W.), Yale University School of Medicine, New Haven, Conn.

Address reprint requests to Dr. Wilson at the Department of Therapeutic Radiology, Yale University School of Medicine, HRT 136, 333 Cedar St., New Haven, CT 06520, or at lynn.wilson@yale.edu.


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