Cutaneous T-cell lymphoma represents a complex array of disorderswith various manifestations, clinical courses, and therapeuticconsiderations. Mycosis fungoides in which the skinis variably affected by flat patches, thin plaques, or tumors is the most common form of cutaneous T-cell lymphoma;consequently, more is understood about it from a basic immunologicand molecular perspective than is understood about the othervariants. The related Sézary syndrome is a more aggressiveform of cutaneous T-cell lymphoma in which the skin is diffuselyaffected and there is measurable involvement within the peripheralblood. In addition to mycosis fungoides and the . . . [Full Text of this Article]
Clinical Features
Skin-Homing Capacity of Malignant Cells
T-Cell Activation
Clonal Dominance of T Cells
Conclusions
Source Information
From the Departments of Dermatology (M.G., P.W.H., L.D.W.) and Therapeutic Radiology (L.D.W.), Yale University School of Medicine, New Haven, Conn.
Address reprint requests to Dr. Wilson at the Department of Therapeutic Radiology, Yale University School of Medicine, HRT 136, 333 Cedar St., New Haven, CT 06520, or at lynn.wilson@yale.edu.
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