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Correspondence
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Volume 350:2001-2003 May 6, 2004 Number 19
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Postmenopausal Osteoporosis and Strontium Ranelate

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by El-Hajj Fuleihan, G.
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by Meunier, P. J.
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To the Editor: Meunier et al. (Jan. 29 issue)1 studied the effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis in a placebo-controlled trial. We are surprised by their statement, "To date, no deleterious effects on the primary or secondary mineralization of bone in laboratory animals or humans have been reported." We found an association between increased levels of bone strontium and osteomalacia in patients undergoing dialysis.2 A worldwide epidemiologic study showed that patients undergoing dialysis were at risk for strontium accumulation.3 The role of strontium in the development of osteomalacia was demonstrated in . . . [Full Text of this Article]



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