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Correspondence
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Volume 350:2010-2011 May 6, 2004 Number 19
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A Halt to Neuroblastoma Screening in Japan

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To the Editor: Neuroblastoma is the most common form of malignant solid tumor during childhood. Japan is the only country in which mass screening for neuroblastoma has been adopted as a national policy, and the program has been conducted since 1984. In 2001, urine samples from 1,170,662 infants six months of age (90.4 percent of eligible infants of that age in Japan) were tested for homovanillic acid and vanilmandelic acid (metabolites of catecholamines produced by neuroblastoma) by high-performance liquid chromatography, and 180 cases of neuroblastoma were detected.

The April 4, 2002, issue of the Journal included reports of screening studies . . . [Full Text of this Article]


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