Polycystic kidney diseases are a leading cause of end-stagerenal failure and a common indication for dialysis or renaltransplantation. Recent advances have led to insights into mechanismsunderlying the cause and prognosis of these diseases and suggestnew directions for treatment.
Polycystic kidney disease may arise sporadically as a developmentalabnormality or may be acquired in adult life, but most formsare hereditary. Among the acquired forms, simple cysts can developin kidneys as a consequence of aging; dialysis, drugs, and hormonescan cause multicystic disease1,2; and renal cysts are oftensecondary manifestations of genetic proliferative syndromes.1The . . . [Full Text of this Article]
Autosomal Dominant Polycystic Kidney Disease
Autosomal Recessive Polycystic Kidney Disease
Familial Nephronophthisis
Medullary Cystic Kidney Disease
Cell Biology
Proliferation and Apoptosis
Secretion
Cell–Matrix Interactions
Polarity
Signal Transduction
Cilia
Molecular Biology
PKD Genes and Mutations
Polycystic Kidney Disease Proteins
Polycystin-1
Polycystin-2
Fibrocystin
Nephrocystin
Functions of Polycystins
Developmental Regulation and Programming
Prospects for Prognosis and Therapy
Source Information
From the Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, New York.
Address reprint requests to Dr. Wilson at the Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, 1425 Madison Ave., East Bldg., Rm. 11-23, New York, NY 10029, or at pat.wilson@mssm.edu.
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