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Previous Volume 350:2068-2079 May 13, 2004 Number 20 Next

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The autoimmune polyendocrine syndromes are diverse, and their diversity is a characteristic that is both clinically important and instructive when their basic immunologic features are considered (Table 1).^1,2,3,4 These syndromes include monogenic disorders (such as autoimmune polyendocrine syndrome type I, which has classic and characteristic disease associations⁵) and complex genetic disorders (such as autoimmune polyendocrine syndrome type II, in which the component diseases are more variable⁶ ). Some of the component disorders are common (e.g., thyroid autoimmunity and celiac disease), whereas others are rare (e.g., Addison's disease and myasthenia gravis). Some of the disorders are usually asymptomatic . . . [Full Text of this Article]

Animal Models of Pathogenesis

Specific Clinical Syndromes

Autoimmune Polyendocrine Syndrome Type I

Autoimmune Polyendocrine Syndrome Type II

X-Linked Polyendocrinopathy, Immune Dysfunction, and Diarrhea

Other Syndromes

Stages in the Development of Autoimmunity with Addison's Disease

Genetic Susceptibility

Triggering of Autoimmunity

Assays for Autoimmune Markers

Progressive Metabolic Abnormalities

Screening Recommendations

Therapy

Source Information

From the Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver.

Address reprint requests to Dr. Eisenbarth at the Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 E. Ninth Ave., Box B140, Denver, CO 80262, or at george.eisenbarth@uchsc.edu.

Related Letters:

Hypoparathyroidism and Autoimmune Polyendocrine Syndromes
Schott M., Scherbaum W. A., Eisenbarth G. S., Gottlieb P.
Extract | Full Text | PDF  
N Engl J Med 2004; 351:1032-1033, Sep 2, 2004. Correspondence

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