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Editorial
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Volume 350:2089-2090 May 13, 2004 Number 20
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Homocysteine and Osteoporotic Fractures — Culprit or Bystander?
Lawrence G. Raisz, M.D.

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 by van Meurs, J. B.J.
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 by McLean, R. R.
-PubMed Citation
Osteoporotic fractures are a major health problem in the industrialized nations, a problem that is likely to become even greater throughout the world as the population ages. One way to prevent osteoporotic fractures is to identify risk factors that can be readily reversed. Epidemiologic studies in the United States and Europe have identified many such factors. For example, supplementation with calcium and vitamin D has been shown to reduce the risk of fracture.

Two studies in this issue of the Journal introduce still another potentially reversible factor: increased circulating homocysteine levels.1,2 There is ample evidence that high homocysteine levels are . . . [Full Text of this Article]


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From the University of Connecticut Center for Osteoporosis, University of Connecticut Health Center, Farmington.


Related Letters:

Homocysteine as a Predictive Factor for Hip Fracture in Older Persons
Auer J., Lamm G., Eber B., Bursztyn M., Pérez-Castrillón J. L., Arranz-Peña M. L., Luis D. D., Ellenberg S. S., Orloff D. G., Temple R. J., McLean R. R., Kiel D. P., van Meurs J. B.J., Pols H. A.P., Uitterlinden A. G., Raisz L. G.
Extract | Full Text | PDF  
N Engl J Med 2004; 351:1027-1030, Sep 2, 2004. Correspondence

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