Osteoporotic fractures are a major health problem in the industrializednations, a problem that is likely to become even greater throughoutthe world as the population ages. One way to prevent osteoporoticfractures is to identify risk factors that can be readily reversed.Epidemiologic studies in the United States and Europe have identifiedmany such factors. For example, supplementation with calciumand vitamin D has been shown to reduce the risk of fracture.
Two studies in this issue of the Journal introduce still anotherpotentially reversible factor: increased circulating homocysteinelevels.1,2 There is ample evidence that high homocysteine levelsare . . . [Full Text of this Article]
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From the University of Connecticut Center for Osteoporosis, University of Connecticut Health Center, Farmington.
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Homocysteine as a Predictive Factor for Hip Fracture in Older Persons
Auer J., Lamm G., Eber B., Bursztyn M., Pérez-Castrillón J. L., Arranz-Peña M. L., Luis D. D., Ellenberg S. S., Orloff D. G., Temple R. J., McLean R. R., Kiel D. P., van Meurs J. B.J., Pols H. A.P., Uitterlinden A. G., Raisz L. G.
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N Engl J Med 2004;
351:1027-1030, Sep 2, 2004.
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