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Previous Volume 350:2126-2128 May 20, 2004 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The fundamental principle of evidence-based medicine is that clinical practice should rest on a sound scientific foundation established by clinical studies involving human subjects. The level of evidence needed for the adoption of new therapies should vary according to the clinical situation, and the higher the stakes, the better the evidence should be. The stakes grow higher in proportion to the size of the affected population, the severity of illness, and the cost of the therapy.

Several therapies in cardiovascular medicine are backed by substantial evidence of high quality. For example, the effects of statin therapy on mortality and the . . . [Full Text of this Article]

Source Information

From the Donald W. Reynolds Cardiovascular Clinical Research Center, Stanford University School of Medicine, Stanford, Calif.

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