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Previous Volume 350:2272-2279 May 27, 2004 Number 22 Next

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Iatrogenic hypoglycemia is the limiting factor in the glycemic management of diabetes.^1,2 It causes recurrent symptomatic and sometimes, at least temporarily, disabling episodes in most people with type 1 diabetes as well as in many with advanced type 2 diabetes, and is sometimes fatal. Furthermore, iatrogenic hypoglycemia precludes maintenance of euglycemia during the lifetime of a person with diabetes and, thus, full realization of the well-established benefits of glycemic control.^3,4,5

In this article, I discuss the clinical problem of hypoglycemia in diabetes from the perspective of pathophysiology. First, the syndromes of defective glucose counterregulation and hypoglycemia without warning symptoms (known . . . [Full Text of this Article]

Defective Glucose Counterregulation and Hypoglycemia Unawareness

Hypoglycemia-Associated Autonomic Failure

Exercise-Related, Hypoglycemia-Associated Autonomic Failure

Sleep-Related, Hypoglycemia-Associated Autonomic Failure

Clinical Implications

Summary

Source Information

From the Division of Endocrinology, Metabolism, and Lipid Research, the General Clinical Research Center, and the Diabetes Research and Training Center, Washington University School of Medicine, St. Louis.

Address reprint requests to Dr. Cryer at Campus Box 8127, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, or at pcryer@wustl.edu.

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