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Volume 350:2305-2306 May 27, 2004 Number 22
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Excision Margins in High-Risk Malignant Melanoma

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 by Krown, S. E.
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 by Thomas, J. M.
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To the Editor: In their article about excision margins for melanoma, Thomas et al. (Feb. 19 issue)1 conclude that a 3-cm margin of excision, as compared with a 1-cm margin, is associated with reduced locoregional recurrences. But is a reduction in locoregional recurrence really associated with fewer melanoma-related deaths? Although the incidence of melanoma-related deaths did not differ significantly between the two study groups (P=0.07 in the multivariate analysis), the magnitude of the benefit with respect to melanoma-related survival was similar to the reduction in locoregional recurrence (hazard ratios for death from melanoma and for locoregional recurrence in the group . . . [Full Text of this Article]




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