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Volume 350:2314 May 27, 2004 Number 22
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Case 6-2004: Severe Burns from a Nightclub Fire

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 by Sheridan, R. L.
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To the Editor: Sheridan et al. (Feb. 19 issue)1 fail to consider that carbonaceous sputum, confusion, agitation, dyspnea, and lactic acidosis in their burned patient are all signs of potential cyanide poisoning from smoke inhalation. This oversight is troubling and, unfortunately, common. Since one of us and our colleagues described the role of cyanide in death due to smoke inhalation and its strong association with increased plasma lactate concentrations,2 numerous investigators have confirmed the importance of cyanide in this setting. The patient under discussion had multiple potential sources of lactate, including possible crush injury, extensive burns, carbon monoxide intoxication, and . . . [Full Text of this Article]




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